Blastocyst grading Morphological grades NUMBER: The degree of the expansion of the embryo’s cavity, ranging from 2-6 2 = cavity fills 1/3 of the embryo 3 = partial expansion, fills 70% of the embryo 4 = fully expanded cavity 5 = embryo has expanded and split open the zona 6 = embryo has completely hatched from the zona FIRST LETTER: The inner cell mass (ICM) quality. A = well-defined clump of ce..